Anti-NaV1.5 (SCN5A) (1978-2016) Antibody

Antibodies

Sodium channel protein type 5 subunit alpha, SKM2

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Sodium channel protein type 5 subunit alpha, SKM2 - A Rabbit Polyclonal Antibody to NaV1.5 (SCN5A) (1978-2016) Channel

Rat - 36/39 amino acid residues identical; mouse - 34/39 amino acid residues identical

Confirmed by DNA sequence and SDS-PAGE

0.8 mg/ml

Intracellular, C-terminus

Human

41116161

Voltage-gated Na+ channels (NaV) are responsible for myocardial conduction and maintenance of the cardiac rhythm and are essential for the generation of action potentials and cell excitability.1Dysfunction or disregulation of cardiac sodium channels can cause several disorders, including cardiac arrhythmias. The majority of Na+ channels in the mammalian heart are Tetrodotoxin (TTX) insensitive NaV1.5.2 The putative structure of NaV1.5 consists of four homologous domain (I-IV), each containing six transmembrane segments (S1-S6). Mutations in the C-terminus of NaV1.5 were described in connection to Long QT syndrome and Brugada syndrome.1-2 Recent data have demonstrated selective expression of NaV1.5 in the mouse central nervous system and implicated a role for NaV1.5 in the physiology of the central nervous system.1