Guinea Pig Anti-Vasopressin V1A Receptor (AVPR1A) Antibody

Antibodies

V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder

V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor - A Guinea Pig Polyclonal Antibody to Vasopressin V1A Receptor (AVPR1A)

Mouse - identical; human - 10 out of 13 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

Intracellular, C-terminus

Rat

41116161

Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonapeptide involved in the homeostasis of body fluid, blood volume, vascular tone, and blood pressure. AVP also belongs to the family of vasoactive and mitogenic peptides involved in physiological and pathological cell growth and differentiation1.AVP exerts its actions through binding to specific V1A, V1B, and V2, membrane receptors coupled to distinct second messengers2. V1 AVP receptor has the typical features of a G-protein coupled transmembrane receptor with seven putative hydrophobic domains, connected by three extracellular and three intracellular loops3.V1 receptors activate phospholipases A2, C, and D, resulting in the production of inositol 1, 4, 5-trisphosphate (IPS) and 1, Z-diacylglycerol (DAG), the mobilization of intracellular Ca2+, the influx of extracellular Ca2+, the activation of protein kinase C, and protein phosphorylation4. V1A AVP receptors have been shown by radioligand binding techniques to be present in vascular smooth muscle cells, hepatocytes, blood platelets, lymphocytes and monocytes, type 2 pneumocytes, adrenal cortex, brain (hippocampus septum et amygdalae), reproductive organs, retinal epithelium, renal mesangial cells, and the A10, A7r5, 3T3, and WRK-1 cell lines4. V1A AVP receptors mediate cell contraction and proliferation, platelet aggregation, coagulation factor release, and glycogenolysis. V1B AVP receptors are located in the anterior pituitary where they stimulate ACTH release1.