Phospho-Rac1/Cdc42-S71 Rabbit mAb

Phosphorylated Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

A synthetic phosphorylated peptide around S71 of human Rac1/Cdc42CDC42 (P60953).

24kDa

GO - Molecular functioni apolipoprotein A-I receptor binding Source: BHF-UCL GBD domain binding Source: CAFA GTPase activity Source: UniProtKB GTP binding Source: UniProtKB GTP-dependent protein binding Source: Ensembl identical protein binding Source: IntAct mitogen-activated protein kinase kinase kinase binding Source: Ensembl protein kinase binding Source: BHF-UCL thioesterase binding Source: UniProtKB ubiquitin protein ligase activity Source: AgBase Complete GO annotation on QuickGO ... GO - Biological processi actin cytoskeleton organization Source: UniProtKB actin filament branching Source: Ensembl actin filament organization Source: UniProtKB adherens junction organization Source: Ensembl blood coagulation Source: Reactome cardiac conduction system development Source: Ensembl Cdc42 protein signal transduction Source: GO_Central cell junction assembly Source: UniProtKB cell projection assembly Source: GO_Central cellular protein localization Source: Ensembl cellular response to interferon-gamma Source: Ensembl dendritic cell migration Source: Ensembl dendritic spine morphogenesis Source: UniProtKB endocytosis Source: GO_Central ephrin receptor signaling pathway Source: Reactome establishment of epithelial cell apical/basal polarity Source: UniProtKB establishment of Golgi localization Source: BHF-UCL establishment or maintenance of cell polarity Source: GO_Central Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome filopodium assembly Source: Ensembl Golgi organization Source: BHF-UCL heart contraction Source: Ensembl integrin-mediated signaling pathway Source: BHF-UCL interleukin-12-mediated signaling pathway Source: Reactome macrophage differentiation Source: UniProtKB modification of synaptic structure Source: GO_Central negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome negative regulation of protein complex assembly Source: UniProtKB neuron fate determination Source: Ensembl neuropilin signaling pathway Source: BHF-UCL nuclear migration Source: Ensembl organelle transport along microtubule Source: BHF-UCL phagocytosis, engulfment Source: UniProtKB positive regulation of actin cytoskeleton reorganization Source: BHF-UCL positive regulation of cell growth Source: AgBase positive regulation of cytokinesis Source: UniProtKB positive regulation of DNA replication Source: Ensembl positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl positive regulation of filopodium assembly Source: BHF-UCL positive regulation of intracellular protein transport Source: Ensembl positive regulation of JNK cascade Source: Ensembl positive regulation of lamellipodium assembly Source: CAFA positive regulation of muscle cell differentiation Source: Reactome positive regulation of neuron apoptotic process Source: Ensembl positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl positive regulation of pseudopodium assembly Source: UniProtKB positive regulation of stress fiber assembly Source: BHF-UCL positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB positive regulation of synapse structural plasticity Source: Ensembl regulation of actin cytoskeleton organization Source: GO_Central regulation of attachment of spindle microtubules to kinetochore Source: UniProtKB regulation of cell shape Source: GO_Central regulation of filopodium assembly Source: UniProtKB regulation of lamellipodium assembly Source: CAFA regulation of mitotic nuclear division Source: Ensembl regulation of modification of postsynaptic structure Source: Ensembl regulation of protein binding Source: Ensembl regulation of small GTPase mediated signal transduction Source: Reactome regulation of stress fiber assembly Source: CAFA Rho protein signal transduction Source: GO_Central sprouting angiogenesis Source: Ensembl submandibular salivary gland formation Source: Ensembl substantia nigra development Source: UniProtKB T cell costimulation Source: Reactome vascular endothelial growth factor receptor signaling pathway Source: Reactome viral RNA genome replication Source: ParkinsonsUK-UCL Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL.

998/5879

CDC42/RAC1