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PGD synthase (M115) polyclonal antibody

PGD synthase (M115) polyclonal antibody

Manufacturer	Bioworld Technology, Inc
Category	Metabolism Cholesterol & Lipid Metabolism Antibodies Western Blot Enzymes Prostaglandin Synthases Primary Antibodies
Type	Antibody Primary
Specific against	Human, Mouse, Rat
Applications	WB
Amount	50ul
Host	Rabbit
Item no.	BS9543-50
Targets	HPGDS;;PTGDS
eClass 6.1	32160702
eClass 9.0	32160702
Available
Swiss-Prot	O60760
Application_all	WB: 1:500ca.1:1000
Background	Glycogen is a polysaccharide of glucose and serves as an energy storage in mammalian muscle and liver (1). Glycogen synthase catalyzes the rate-limiting step of glycogen biosynthesis and has two major isoforms in mammals -- muscle isoform (GYS1) and liver isoform (GYS2) respectively. Glycogen synthase kinase-3alpha (GSK-3alpha) and glycogen synthase kinase-3beta (GSK-3beta) phosphorylate glycogen synthase at multiple sites in its C-terminus (Ser641, Ser645, Ser649 and Ser653) inhibiting its activity. Hypoxia alters glycogen metabolism including temporal changes of GYS1 expression and phosphorylation in cancer cells, suggesting the role of metabolic reprogramming of glycogen metabolism in cancer growth.
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification And Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage And Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	PGD synthase (M115) polyclonal antibody endogenous levels of PGD synthase protein.
BiowMW	ca. 23 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Synthetic peptide, corresponding to amino acids 55-175 of PGD synthase

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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