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AIFM1 Antibody

AIFM1 Antibody

Item no.	CSB-PA001492HA01HU-50ug
Manufacturer	Cusabio
Amount	50 ug
Quantity options	100 ug 20 ug 50 ug
Category	Neuroscience Neural Lineage Markers Antibodies Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies Microglia Markers
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AIFM1 antibody; AIFM1_HUMAN antibody; Apoptosis inducing factor 1, mitochondrial antibody; Apoptosis inducing factor antibody; Apoptosis inducing factor, mitochondrion associated, 1 antibody; Apoptosis-inducing factor 1 antibody; CMTX4 antibody; COWCK antibody; COXPD6 antibody; Harlequin antibody; Hq antibody; mAIF antibody; MGC111425 antibody; MGC5706 antibody; mitochondrial antibody; Neuropathy, axonal motor-sensory, with deafness and mental retardation antibody; neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome) antibody; PDCD 8 antibody; PDCD8 antibody; Programmed cell death 8 (apoptosis inducing factor) antibody; Programmed cell death 8 antibody; Programmed cell death 8 isoform 1 antibody; Programmed cell death 8 isoform 2 antibody; Programmed cell death 8 isoform 3 antibody; Programmed cell death protein 8 antibody; Programmed cell death protein 8 mitochondrial antibody; Programmed cell death protein 8 mitochondrial precursor antibody; Programmed cell death protein 8 mitochondrial precursor antibody; Striatal apoptosis inducing factor antibody
Similar products	AIFM1, Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8), AIF PDCD8
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Targets	Histone H2B
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Manufacturer - Alias	AIFM1 antibody; AIFM1_HUMAN antibody; Apoptosis inducing factor 1, mitochondrial antibody; Apoptosis inducing factor antibody; Apoptosis inducing factor, mitochondrion associated, 1 antibody; Apoptosis-inducing factor 1 antibody; CMTX4 antibody; COWCK antibody; COXPD6 antibody; Harlequin antibody; Hq antibody; mAIF antibody; MGC111425 antibody; MGC5706 antibody; mitochondrial antibody; Neuropathy, axonal motor-sensory, with deafness and mental retardation antibody; neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome) antibody; PDCD 8 antibody; PDCD8 antibody; Programmed cell death 8 (apoptosis inducing factor) antibody; Programmed cell death 8 antibody; Programmed cell death 8 isoform 1 antibody; Programmed cell death 8 isoform 2 antibody; Programmed cell death 8 isoform 3 antibody; Programmed cell death protein 8 antibody; Programmed cell death protein 8 mitochondrial antibody; Programmed cell death protein 8 mitochondrial precursor antibody; Programmed cell death protein 8 mitochondrial precursor antibody; Striatal apoptosis inducing factor antibody
Immunogen Species	Human
Immunogen	Recombinant Human Apoptosis-inducing factor 1, mitochondrial protein (103-612AA)
Dilution	ELISA:1:2000-1:10000 WB:1:500-1:5000 IHC:1:1000-1:2000 IF:1:200-1:500
Background	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method	>95%, Protein G purified
General Research Areas	Cell Biology
Initial Research Areas	Cell Biology
Antigen Species	Human
Antigen	Recombinant Human Apoptosis-inducing factor 1, mitochondrial protein (103-612AA)
Clonality	Polyclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 8/14/2025

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