CCND3 Antibody

ELISA,  WB,  IF;  Recommended dilution: WB:1:5000-1:2000,  IF:1:20-1:100

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Recombinant Human G1/S-specific cyclin-D3 protein (1-292AA)

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Antigen Affinity Purified

Human

Polyclonal