NTHL1 Antibody

NTHL1

Bifunctional DNA N glycoslyase/DNA (apurinic or apyrimidinic site) lyase antibody; DNA glycoslyase/AP lyase antibody; Endonuclease III like protein 1 antibody; Endonuclease III-like protein 1 antibody; hNTH1 antibody; NTH 1 antibody; nth endonuclease III like 1 (E. coli) antibody; NTH endonuclease III Like 1 antibody; NTH1 antibody; NTHL 1 antibody; Nthl1 antibody; NTHL1_HUMAN antibody; OCTS 3 antibody; OCTS3 antibody

Recombinant Human Endonuclease III-like protein 1 protein (31-312AA)

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7, 8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

>95%, Protein G purified

Epigenetics and Nuclear Signaling

Recombinant Human Endonuclease III-like protein 1 protein (31-312AA)