PTPRB Antibody

Polyclonal Antibody

PTPRB

HPTP BETA antibody, HPTPB antibody, Phosphacan receptor type B antibody, Protein tyrosine phosphatase receptor type B antibody, Protein-tyrosine phosphatase beta antibody, PTPB antibody, Ptprb antibody, PTPRB_HUMAN antibody, R PTP BETA antibody, R-PTP-beta antibody, Receptor-type tyrosine-protein phosphatase beta antibody, RPTPB antibody, Vascular endothelial protein tyrosine phosphatase antibody, VE-PTP antibody

Recombinant Human Receptor-type tyrosine-protein phosphatase beta protein (1758-1997AA)

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Antigen Affinity Purified

Human

Polyclonal