TAP1 Antibody

Polyclonal Antibody

TAP1

ABC 17 antibody, ABC transporter MHC 1 antibody, ABC17 antibody, ABCB 2 antibody, ABCB2 antibody, Antigen peptide transporter 1 antibody, APT 1 antibody, APT1 antibody, ATP binding cassette sub family B (MDR/TAP) member 2 antibody, ATP binding cassette sub family B member 2 antibody, ATP binding cassette transporter antibody, ATP-binding cassette sub-family B member 2 antibody, D6S114E antibody, FLJ26666 antibody, FLJ41500 antibody, Peptide supply factor 1 antibody, Peptide transporter involved in antigen processing 1 antibody, Peptide transporter PSF 1 antibody, Peptide transporter PSF1 antibody, Peptide transporter TAP 1 antibody, Peptide transporter TAP1 antibody, PSF 1 antibody, PSF-1 antibody, PSF1 antibody, Really interesting new gene 4 protein antibody, RING 4 antibody, RING4 antibody, TAP 1 antibody, TAP1 antibody, TAP1*0102N antibody, TAP1_HUMAN antibody, TAP1N antibody, Transporter 1 ATP binding cassette sub family B (MDR/TAP) antibody, Transporter 1 ATP binding cassette sub family B antibody, Transporter associated with antigen processing antibody, Transporter ATP binding cassette major histocompatibility complex 1 antibody, Y3 antibody

Recombinant Human Antigen peptide transporter 1 protein (524-808AA)

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Antigen Affinity Purified

Signal Transduction

Recombinant Human Antigen peptide transporter 1 protein (524-808AA)