TDP1 Antibody

TDP1

AI838772 antibody; AW493413 antibody; FLJ11090 antibody; MGC104252 antibody; MGC112732 antibody; RP24-311F12.2 antibody; SCAN1 antibody; TDP1 antibody; TYDP antibody; TYDP1_HUMAN antibody; Tyr-DNA phosphodiesterase 1 antibody; Tyrosyl-DNA phosphodiesterase 1 antibody

Recombinant Human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA)

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.

Antigen Affinity Purified

Epigenetics and Nuclear Signaling

Recombinant Human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA)