ULK1 Antibody

ULK1

ATG 1 antibody; ATG1 antibody; ATG1 autophagy related 1 homolog antibody; ATG1A antibody; Autophagy related protein 1 homolog antibody; Autophagy-related protein 1 homolog antibody; FLJ38455 antibody; FLJ46475 antibody; hATG1 antibody; KIAA0722 antibody; Serine/threonine protein kinase ULK1 antibody; Serine/threonine protein kinase Unc51.1 antibody; Serine/threonine-protein kinase ULK1 antibody; ULK 1 antibody; ULK1 antibody; ULK1_HUMAN antibody; Unc 51 (C. elegans) like kinase 1 antibody; UNC 51 antibody; Unc 51 like kinase 1 antibody; Unc-51 like kinase 1 (C. elegans) antibody; Unc-51-like kinase 1 antibody; UNC51 antibody; UNC51; C. elegans; homolog of antibody; Unc51.1 antibody

Recombinant Human Serine/threonine-protein kinase ULK1 protein (602-715AA)

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

>95%, Protein G purified

Signal Transduction

Recombinant Human Serine/threonine-protein kinase ULK1 protein (602-715AA)