Phospho-CDKN1A (Thr145) Antibody

Polyclonal Antibody

CDKN1A

CAP20 antibody, CDK-interacting protein 1 antibody, CDKI antibody, CDKN1 antibody, Cdkn1a antibody, CDN1A_HUMAN antibody, CIP1 antibody, Cyclin Dependent Kinase Inhibitor 1A antibody, Cyclin-dependent kinase inhibitor 1 antibody, Cyclin-dependent kinase inhibitor 1A (P21) antibody, Cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody, DNA Synthesis Inhibitor antibody, MDA-6 antibody, MDA6 antibody, Melanoma differentiation-associated protein 6 antibody, Melanoma differentiation-associated protein antibody, p21 antibody, P21 protein antibody, p21CIP1 antibody, p21Cip1/Waf1 antibody, p21WAF antibody, PIC1 antibody, SDI1 antibody, SLC12A9 antibody, WAF1 antibody, Wild type p53 activated fragment 1 (WAF1) antibody, Wild type p53 activated fragment 1 antibody, Wildtype p53-activated fragment 1 antibody

Peptide sequence around phosphorylation site of threonine 145 (R-Q-T(p)-S-M) derived from Human p21Cip1.

May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

Ocker M Int, et al. (2007)J Biochem Cell Biol. 39(7-8):1367-74.
Dangi S, et al.(2006)Cell Prolif. 39(4):261-79.
Chen J, et al.(2006)Am J Physiol Heart Circ Physiol. 290(4):H1575-86

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Cell Biology

Peptide sequence around phosphorylation site of threonine 145 (R-Q-T(p)-S-M) derived from Human p21Cip1.