STRADB Antibody

Polyclonal Antibody

STRADB

ALS2 chromosome region gene 2 antibody, ALS2CR2 antibody, Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 2 antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein antibody, CALS 21 antibody, CALS-21 antibody, ILP interacting protein ILPIPA antibody, ILP-interacting protein antibody, ILPIP antibody, ILPIPA antibody, Likely ortholog of mouse polyploidy associated protein kinase antibody, PAPK antibody, PRO1038 antibody, Pseudokinase ALS2CR2 antibody, STE20-related kinase adapter protein beta antibody, STRAB_HUMAN antibody, STRAD beta antibody, STRADB antibody

Fusion protein of human STRADB

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Antigen Affinity Purified

Neuroscience

Human

Polyclonal