DCLK1 Antibody

DCLK1

Calcium/calmodulin-dependent protein kinase type I-like CPG16 antibody; CL1 antibody; CLICK1 antibody; Cpg16 antibody; DCDC3A antibody; Dcl antibody; Dclk antibody; Dclk1 antibody; DCLK1_HUMAN antibody; Doublecortin domain-containing protein 3A antibody; Doublecortin-like and CAM kinase-like 1 antibody; Doublecortin-like kinase 1 antibody; KIAA0369 antibody; Serine/threonine-protein kinase DCAMKL1 antibody; Serine/threonine-protein kinase DCLK1 antibody

Synthetic peptide of human DCLK1

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

Antigen affinity purification

Neuroscience

Synthetic peptide of Human DCLK1