IL12RB1 Antibody

Polyclonal Antibody

IL12RB1

CD212 antibody, cluster of differentiation 212 antibody, I12R1_HUMAN antibody, IL-12 receptor beta component antibody, IL-12 receptor subunit beta-1 antibody, IL-12R subunit beta-1 antibody, IL-12R-beta-1 antibody, IL-12RB1 antibody, IL12 receptor beta component antibody, IL12RB antibody, Il12rb1 antibody, IMD3 antibody, IMD30 antibody, Interleukin 12 receptor beta 1 chain antibody, Interleukin 12 receptor subunit beta 1 antibody, Interleukin-12 receptor subunit beta-1 antibody, MGC34454 antibody

Fusion protein of human IL12RB1

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Antigen Affinity Purified

Immunology

Fusion protein of Human IL12RB1