IFNL3 Antibody

IFNL3

Cytokine ZCYTO22 antibody; IFN-lambda-3 antibody; IFN-lambda-4 antibody; IL-28B antibody; IL-28C antibody; IL28B antibody; IL28B_HUMAN antibody; IL28C antibody; Interferon lambda-3 antibody; Interferon lambda-4 antibody; interleukin 28B (interferon; lambda 3) antibody; Interleukin 28C antibody; Interleukin-28B antibody; Interleukin-28C antibody

Recombinant Human Interferon lambda-3 protein (22-196AA)

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Antigen Affinity Purified

Immunology

Recombinant Human Interferon lambda-3 protein (22-196AA)