MED12 Antibody

Polyclonal Antibody

MED12

Activator recruited cofactor 240 kDa component antibody, Activator-recruited cofactor 240 kDa component antibody, ARC240 antibody, CAG repeat protein 45 antibody, CAGH45 antibody, HOPA antibody, KIAA0192 antibody, MED12 antibody, MED12_HUMAN antibody, Mediator complex subunit 12 antibody, Mediator of RNA polymerase II transcription subunit 12 antibody, OPA containing protein antibody, OPA-containing protein antibody, Thyroid hormone receptor associated protein complex 230 kDa component antibody, Thyroid hormone receptor-associated protein complex 230 kDa component antibody, TNRC11 antibody, Trap230 antibody, Trinucleotide repeat containing gene 11 protein antibody, Trinucleotide repeat-containing gene 11 protein antibody

Synthetic peptide of human MED12

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.

Antigen Affinity Purified

Epigenetics and Nuclear Signaling

Synthetic peptide of Human MED12