CDK5R1 Antibody

Polyclonal Antibody

CDK5R1

CD5R1_HUMAN antibody, CDK5 activator 1 antibody, CDK5P35 antibody, CDK5R antibody, CDK5R1 antibody, Cyclin dependent kinase 5 regulatory subunit 1 antibody, Cyclin-dependent kinase 5 activator 1 antibody, Cyclin-dependent kinase 5 regulatory subunit 1 antibody, NCK 5A antibody, Neuronal CDK5 activator antibody, p23 antibody, p25 antibody, p35 antibody, Regulatory partner for CDK5 kinase antibody, Tau protein kinase II 23 kDa subunit antibody, TPKII regulatory subunit antibody

Synthesized peptide derived from internal of human CDK5R1.

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Tsai L.-H., Nature 371:419-423(1994).
Patrick G.N., Nature 402:615-622(1999).
Kesavapany S., J. Neurosci. 24:4421-4431(2004).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from internal of Human CDK5R1.