CCNL1 Antibody

ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Synthesized peptide derived from human Cyclin-L1.

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.

A. Hamid Boulares, J. Biol. Chem., Aug 1999, 274: 22932.
Alessandra Pagano, Am J Physiol Lung Cell Mol Physiol, Jun 2007, 10.1152.
Mi Young Kim, Genes & Dev., Sep 2005, 19: 1951 - 1967.
Silke S???e, Nucleic Acids Res., Feb 2004, 32: 669 - 680.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Epigenetics and Nuclear Signaling

Synthesized peptide derived from Human Cyclin-L1.