Comparison

Phospho-RB1 (S807) Recombinant Monoclonal Antibody

Item no. CSB-RA019386A807phHU-50ul
Manufacturer Cusabio
Amount 50 ul
Quantity options 100 ul 50 ul
Category
Type Antibody Monoclonal
Format Liquid
Applications IF, ELISA
Clone 1H3
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1
Similar products Rb, RB1, Retinoblastoma-associated protein, p105-Rb, pRb, pp110
Available
Manufacturer - Type
Recombinant Antibody
Manufacturer - Applications
ELISA, IF; Recommended dilution: IF:1:20-1:200
Manufacturer - Isotype
Rabbit IgG
Manufacturer - Targets
RB1
Storage Conditions
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Immunogen
A synthesized peptide derived from human Phospho-RB1 (S807)
Dilution
IF:1:20-1:200
Background
Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
Buffer
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method
Affinity-chromatography
General Research Areas
Cell Biology
Modified
Cell Biology
Antigen Species
Human
Antigen
A synthesized peptide derived from human Phospho-RB1 (S807)
Clonality
Monoclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 ul
Available: In stock
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