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SIRT5 Recombinant Monoclonal Antibody

SIRT5 Recombinant Monoclonal Antibody

Item no.	CSB-RA156557A0HU-50ul
Manufacturer	Cusabio
Amount	50 ul
Quantity options	100 ul 50 ul
Category	Oncology Antibodies By Cell Type Immunohistochemistry ELISA Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	IHC, ELISA
Clone	9H12
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5), SIRT5, SIR2L5
Similar products	SIRT5, SIR2L5, NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
Available
Manufacturer - Type	Recombinant Antibody
Manufacturer - Applications	ELISA, IHC; Recommended dilution: IHC:1:50-1:200
Manufacturer - Isotype	Rabbit IgG
Manufacturer - Targets	SIRT5
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Immunogen	A synthesized peptide derived from human SIRT5
Dilution	IHC:1:50-1:200
Background	NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method	Affinity-chromatography
General Research Areas	Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism
Modified	Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism
Antigen Species	Human
Antigen	A synthesized peptide derived from human SIRT5
Clonality	Monoclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 9/4/2025

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