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RNF20 Recombinant Monoclonal Antibody

RNF20 Recombinant Monoclonal Antibody

Item no.	CSB-RA227095A0HU-50ul
Manufacturer	Cusabio
Amount	50 ul
Quantity options	100 ul 50 ul
Category	Neuroscience Aging & Neurological Disorders Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot ELISA Immunofluorescence Autophagy Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Clone	2H12
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A),RNF20,BRE1A
Similar products	RNF20, BRE1A, E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Available
Manufacturer - Type	Recombinant Antibody
Manufacturer - Applications	ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200
Manufacturer - Isotype	Rabbit IgG
Manufacturer - Targets	RNF20
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Immunogen	A synthesized peptide derived from human RNF20
Dilution	WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200
Background	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
Buffer	Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Purification Method	Affinity-chromatography
General Research Areas	Cell biology
Modified	Cell biology
Antigen Species	Human
Antigen	A synthesized peptide derived from human RNF20
Clonality	Monoclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 1/29/2026

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