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AIFM1 Recombinant Monoclonal Antibody

AIFM1 Recombinant Monoclonal Antibody

Item no.	CSB-RA296617A0HU-100ul
Manufacturer	Cusabio
Amount	100 ul
Quantity options	100 ul 50 ul
Category	Neuroscience Neural Lineage Markers Antibodies Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies Microglia Markers
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC, ELISA
Clone	4B2
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8), AIFM1, AIF PDCD8
Similar products	AIFM1, Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8), AIF PDCD8
Available
Manufacturer - Type	Recombinant Antibody
Manufacturer - Applications	ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200
Manufacturer - Isotype	Rabbit IgG
Manufacturer - Targets	AIFM1
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Immunogen	A synthesized peptide derived from human AIF
Dilution	WB:1:500-1:5000, IHC:1:50-1:200
Background	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method	Affinity-chromatography
General Research Areas	Epigenetics and Nuclear Signaling; Cancer; Cell biology; Metabolism
Modified	Epigenetics and Nuclear Signaling; Cancer; Cell biology; Metabolism
Antigen Species	Human
Antigen	A synthesized peptide derived from human AIF
Clonality	Monoclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 8/14/2025

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