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BAX antibody

BAX antibody

Item no.	FNab00810-100ug
Manufacturer	FineTest
Amount	100 ug
Quantity options	100 ug 100 ug 100 ug 100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, FC, IP, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Rabbit (Oryctolagus cuniculus), Sheep (Ovine, Ovis aries)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Apoptosis regulator BAX,Bcl-2-like protein 4 (Bcl2-L-4),BAX,BCL2L4
Available
Manufacturer - Targets	BAX
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).
Clonality	polyclonal
Immunogen	BCL2-associated X protein
Observed MW	21 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:1000-1:10000; IP: 1:1000-1:10000; IHC: 1:20-1:200
Manufacturer - Research Area	Neuroscience, Cancer, Developmental biology

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