Item no. |
FNab00842-100ug |
Manufacturer |
FineTest
|
Amount |
100 ug |
Quantity options |
100 ug
100 ug
|
Category |
|
Type |
Antibody Monoclonal |
Format |
Liquid |
Applications |
WB, IF, IHC, ELISA |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Isotype |
IgG |
Purity |
≥95% as determined by SDS-PAGE |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Bcl-2-like protein 1 (Bcl2-L-1),Apoptosis regulator Bcl-X,BCL2L1,BCL2L,BCLX |
Available |
|
Manufacturer - Targets |
Bcl-XL |
Storage Conditions |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.) |
Background |
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel(VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis. |
Clonality |
polyclonal |
Immunogen |
BCL2-like 1 |
Observed MW |
30 kDa |
Purification |
Immunogen affinity purified |
Recommended dilution |
WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500 |
Manufacturer - Research Area |
Neuroscience, Cancer, Immunology, Cardiovascular |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.