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BCL2L1 antibody

BCL2L1 antibody

Item no.	FNab00843-100ug
Manufacturer	FineTest
Amount	100 ug
Quantity options	100 ug 100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Clone	2A9
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Bcl-2-like protein 1 (Bcl2-L-1),Apoptosis regulator Bcl-X,BCL2L1,BCL2L,BCLX
Available
Manufacturer - Targets	BCL2L1
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel(VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis.
Clonality	monoclonal
Immunogen	BCL2-like 1
Observed MW	35 kDa
Purification	Protein A+G purification
Recommended dilution	WB: 1:2000-1:20000; IHC: 1:200-1:600; IF: 1:10-1:100
Manufacturer - Research Area	Neuroscience, Cancer, Immunology, Cardiovascular

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