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anti- BCL2L1 antibody

anti- BCL2L1 antibody

Manufacturer	FineTest
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Specific against	Human
Clone	2A9
Isotype	IgG2a
Format	liquid
Amount	100ug
Host	Mouse
Item no.	FNab00843-100ug
eClass 6.1	32160702
eClass 9.0	32160702
Available
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Clonality	monoclonal
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel(VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis.
Immunogen	BCL2-like 1
Observed MW	35 kDa
Uniprot ID	Q07817
Tested Application	ELISA, WB, IHC, IF
Recommended dilution	WB: 1:2000-1:20000; IHC: 1:200-1:600; IF: 1:10-1:100
Gene ID	598
Research Area	Neuroscience, Cancer, Immunology, Cardiovascular

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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Delivery expected until 8/2/2023