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WTAP antibody

WTAP antibody

Item no.	FNab09530-100ug
Manufacturer	FineTest
Amount	100 ug
Quantity options	100 ug 100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC, ELISA
Clone	9D4
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG1
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Pre-mRNA-splicing regulator WTAP,Female-lethal(2)D homolog (hFL(2)D),WT1-associated protein,Wilms tumor 1-associating protein,WTAP,KIAA0105
Available
Manufacturer - Targets	WTAP
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).
Clonality	monoclonal
Immunogen	Wilms tumor 1 associated protein
Observed MW	49 kDa
Purification	Protein A+G purification
Recommended dilution	WB: 1:1000-1:10000; IHC: 1:50-1:500
Manufacturer - Research Area	Epigenetics

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