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Bulk Anti-Human CD8 (UCHT-4) Antibody

Bulk Anti-Human CD8 (UCHT-4) Antibody

Item no.	ICH1005-5MG
Manufacturer	IchorBio
Amount	5 mg
Quantity options	100 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Antibodies In Vivo Antibodies By Cell Type Hematology Leukemia Flow Cytometry Western Blot
Type	Antibody
Applications	WB, FC, IF, IP, IHC, ELISA, FA
Clone	UCHT-4
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a
Purity	>95% by SDS-PAGE and HPLC
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	in vivo
Shipping condition	Cool pack
Available
Specificity	Anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) recognizes Human CD8. Anti-Human CD8 recognizes a T-cell glycoprotein cell surface complex (Mr 32 kDa) which defines the cytotoxic/suppressor population of mature T-lymphocytes. The CD8 complex interacts
Manufacturer - Applications	Flow Cytometry, Western Blot, Immunoprecipitation, Functional Assays, IHC, Immunofluorescence, ELISA
Manufacturer - Category	Low Endotoxin, anti-human, monoclonal antibody
Manufacturer - Isotype	Mouse IgG2a
Manufacturer - Targets	CD8
Shipping Temperature	Blue ice
Storage Conditions	anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Aggregation	Aggregation level ≤ 5%
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Antigen Distribution	The CD8 antigen is expressed on approximately 19-48% of normal human peripheral blood lymphocytes and > 90% of normal thymocytes. It is also present on a subset of NK cells. Subjects infected with HIV have been shown to exhibit increased levels of CD8+ lymphocytes with a continual decrease in CD4+ lymphocytes.
Application Notes	Each investigator should determine their own optimal working dilution for specific applications.
Background	Anti-CD8 may be used in studies of immunoregulation and T-lymphocyte mediated suppression, autoimmune disorders, immunodeficiency states and acute lymphoblastic leukemia and lymphoma.
Concentration	1.0 - 5.0 mg/ml
Endotoxin	<1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity	Anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) recognizes Human CD8. Anti-Human CD8 recognizes a T-cell glycoprotein cell surface complex (Mr 32 kDa) which defines the cytotoxic/suppressor population of mature T-lymphocytes. The CD8 complex interacts with class I MHC molecules resulting in increased adhesion between CD8+ T-lymphocytes and their target cells. Binding of the CD8 antigen to Class I MHC molecules enhances T-cell activation. The cytoplasmic portion of the CD8 antigen is associated with a protein tyrosine kinase (p56lck).
Purification method	This monoclonal antibody was purified using Protein A
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Antibodies against the same target (Cat No.)	ICH1043-100MG, AICH1043UL-100MG
Isotype Control	Mouse IgG2a In Vivo Isotype Control - Low Endotoxin [C1.18.4] (ICH2245)
Buffer	ICH3001-100ml; ICH3002-100ml; ICH3003-100ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 6/5/2025