Anti-CD115 (AFS98) In Vivo Antibody - Low Endotoxin

Western Blot, Blocking, Functional Assays, Flow Cytometry

Rat IgG2a Kappa

Blue ice

Aggregation level ≤ 5%

Monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, osteoclasts

Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. It also triggers growth and development of mononuclear phagocytes and placental trophoblasts. M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion.

≤ 1.0 EU/mg as determined by the LAL method

This monoclonal antibody was purified using Protein G

Purified Recombinant Mouse M-CSFR

Rat IgG2a In Vivo Isotype Control - Low Endotoxin [1-1] (ICH2244)