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Anti-Mouse CD25 - Purified - 500 µg

Anti-Mouse CD25 - Purified - 500 µg

Item no.	LEIN-C1189-500ug
Manufacturer	Leinco Technologies
Amount	500 ug
Quantity options	100 ug 500 ug
Category	Neuroscience Neural Lineage Markers Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies Functional Assays
Type	Antibody Monoclonal
Applications	WB, FC, IP, IHC, FA, other
Clone	PC61
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Citations	1. Warren J. Leonard et al. (2002) The EMBO Journal 21: 3051 2. FW Alt et al. (1995) Immnnity 3: 521 3. Greene WC et al. (1990) J Invest Dermatol. 94: 27S
NCBI	16184
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	B, Depletion, FA, FC, IHC FF, IP, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Surfacetag Mouse CD Markers
Manufacturer - Targets	CD25
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This purified antibody is stable when stored at 2-8°C. Do not freeze.
Product Description	CD25, a 55 kD type I transmembrane glycoprotein, has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Many resting memory T cells constitutively express IL2RA. It functions as the receptor for HTLV-1, resulting in its expression on neoplastic cells in adult T cell lymphoma/leukemia. CD25 (sIL-2R) has been used to track disease progression. Some additional clinical applications include Chagas disease, a disease characterized by a decline of CD25 expression on immune cells, and Multiple sclerosis, in which treatments with mAbs target CD25.
Background	CD25, a 55 kD type I transmembrane glycoprotein, has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Many resting memory T cells constitutively express IL2RA. It functions as the receptor for HTLV-1, resulting in its expression on neoplastic cells in adult T cell lymphoma/leukemia. CD25 (sIL-2R) has been used to track disease progression. Some additional clinical applications include Chagas disease, a disease characterized by a decline of CD25 expression on immune cells, and Multiple sclerosis, in which treatments with mAbs target CD25.
Other Applications Reported In Literature	CODEX® B Depletion IHC (Frozen) IP FA
PubMed	CD25
Ligand/Receptor	IL-2
Manufacturer - Research Area	Immunology
Manufacturer - Specificity	Clone PC61 recognizes an epitope on mouse CD25.
RRID	AB_2828354
Concentration	0.5 mg/ml
Formulation	This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	CD25 is expressed in activated T cells and B cells, thymocyte subset, pre-B cells, T regulatory cells.
Immunogen	IL-2-dependent cytolytic mouse T-cell clone B6.1
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Interleukin-2 Receptor Alpha, IL2RA, IDDM10, CD25, IL2R, TCGFR, P55, Tac, PC61, IL-2 Rα, Mouse, Anti-Mouse IL-2 Rα-Purified

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-C1189-500ug-safety-datasheet.pdf