« Back
Home /
Anti-Human F1A-alpha (CT)

Anti-Human F1A-alpha (CT)

Item no.	LEIN-F143-1mg
Manufacturer	Leinco Technologies
Amount	1 mg
Quantity options	0.1 mg 0.5 mg 1 mg 20 ug
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Primary
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Chan, SL. et al. (1999) J Biol Chem. 274(45):32461-8. 2. Ventura-Holman, T. and Maher, JF. (2000) Biochem Biophys Res Commun 267(1):317-20 3. Chan, SL. et al. (2000) J Biol Chem. 275 (24):17925-8.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	F1A-α
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aα and FEM1b.1, 2 F1Aα/FEM1β is the homologue of C. elegans sex determining protein FEM-1.1, 2 FEM-1/F1Aα is cleaved by CED-3 and caspase.3 FEM-1/F1Aα associates with CED-4 and its mammalian homologue Apaf-1.3 Overexpression of F1Aα induces apoptosis. F1Aα is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aα is expressed in a variety of human and mouse tissues.1, 2
Background	Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aα and FEM1b.^{1, 2} F1Aα/FEM1β is the homologue of C. elegans sex determining protein FEM-1.^{1, 2} FEM-1/F1Aα is cleaved by CED-3 and caspase.³ FEM-1/F1Aα associates with CED-4 and its mammalian homologue Apaf-1.³ Overexpression of F1Aα induces apoptosis. F1Aα is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aα is expressed in a variety of human and mouse tissues.^{1, 2}
PubMed	F1A-α
Manufacturer - Specificity	Rabbit Anti-Human F1A-α recognizes an epitope near the C-terminus of mouse, rat and human F1A-α. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2830182
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:F144
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

LEIN-F143-1mg-safety-datasheet.pdf