Anti-Human F1A-α (CT) - 20 µg

Primary Monoclonal Antibodies>Apoptosis & Cell Biology

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Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aα and FEM1b.1, 2 F1Aα/FEM1β is the homologue of C. elegans sex determining protein FEM-1.1, 2 FEM-1/F1Aα is cleaved by CED-3 and caspase.3 FEM-1/F1Aα associates with CED-4 and its mammalian homologue Apaf-1.3 Overexpression of F1Aα induces apoptosis. F1Aα is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aα is expressed in a variety of human and mouse tissues.1, 2

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Polyclonal Antibody, F1A-α, FEM1-β, F1A-α, Human, Anti-Human F1A-α (CT)