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Anti-Human IFN-γ R1 - 100 µg

Anti-Human IFN-γ R1 - 100 µg

Item no.	LEIN-I-730-100ug
Manufacturer	Leinco Technologies
Amount	100 ug
Quantity options	100 ug 25 ug
Category	Antibodies Western Blot Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Primary
Applications	WB, ICC
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Calderon, J. et al. (1988) PNAS 85: 4837 2. Garcia-Sastre, A. et al. (2002) Int. Rev. Immunol. 21: 305 3. Fish, E. et al. (2002) J. Interferon Cytokine Res. 22: 835
NCBI	3459
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	ICC, N, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	IFN-gamma R1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	IFN-γ receptor ligand-binding chain (IFNγR1) or IFN-γ R α chain, also known CDw119, is member of the class II cytokine receptor family. The IFN-γ receptor is a complex of a high affinity IFN-γ-binding chain (aka, IFN-γ R α chain) and a second accessory protein required for signal transduction known as IFN-γ R β chain. Binding of IFN-γ induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.1, 2, 3
Background	IFN-γ receptor ligand-binding chain (IFNγR1) or IFN-γ R α chain, also known CDw119, is member of the class II cytokine receptor family. The IFN-γ receptor is a complex of a high affinity IFN-γ-binding chain (aka, IFN-γ R α chain) and a second accessory protein required for signal transduction known as IFN-γ R β chain. Binding of IFN-γ induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.^{1, 2, 3}
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Human IFN-γ R1 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human IFN-γ R1 (at 2 ng/ml) is 0.5 - 2.0 µg/ml. Immunocytochemistry: Suitable for use at concentration of5-15 µg/mL.
PubMed	IFN-gamma R1
Manufacturer - Specificity	Goat Anti-Human Interferon Gamma Receptor 1 (IFN-γ R1) recognizes Human IFN-γ R1. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2830851
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered in modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 with concentration 1.648 and no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	NS0-Derived Recombinant Human Interferon-γ Receptor 1 Extracellular Domain
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Interferon Gamma Receptor 1, CD119, IFN-γR, IFN-γRα, IFN-α R1, CDw119, IFN-γ R1, Human IFN-γ R1, Anti-Human IFN-γ R1, AVP, type 2; CD119 antigen, CD119, FLJ45734, IFN-gamma R1, IFN-gamma receptor 1, IFNgammaR1, IFN-gamma-R1, IFNGR, IFNGR1, IFN-gR1, immune interferon receptor 1, interferon gamma receptor 1, interferon-gamma receptor alpha chain, type 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-730-100ug-safety-datasheet.pdf