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Anti-Human Transmembrane Activator & CAML Interactor (TACI)

Anti-Human Transmembrane Activator & CAML Interactor (TACI)

Item no.	LEIN-T221-25ug
Manufacturer	Leinco Technologies
Amount	25 ug
Quantity options	100 ug 25 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC, other
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Schwaller, J. et al. (2007) Blood 109:331 2. Slazer, U. et al. (2005) Nat Genet. 37:820 3. Bonilla, FA. et al. (2006) Curr Allergy Asthma Rep. 6:357 4. Bram, RJ. et al. (2000) Mamm Genome. 11:628 5. Kobata, T. et al. (2007) Blood 109: 2961
NCBI	23495
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	Quality Tested by Leinco Western Blot: Suitable for use at concentration of0.1 µg/mL.
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	TACI
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Transmembrane activator & calcium modulator and cyclophilin ligand (CAML) interactor (TACI) is lymphocyte specific member1, 2 of the tumor necrosis factor-receptor superfamily3 and is expressed in B-lymphocytes and may act to regulate humoral immunity.4 TACI also serves as a receptor for B-cell activating factor of the TNF family (BAFF) and as a proliferation-inducing ligand (APRIL).5
Background	Transmembrane activator & calcium modulator and cyclophilin ligand (CAML) interactor (TACI) is lymphocyte specific member^{1, 2} of the tumor necrosis factor-receptor superfamily³ and is expressed in B-lymphocytes and may act to regulate humoral immunity.⁴ TACI also serves as a receptor for B-cell activating factor of the TNF family (BAFF) and as a proliferation-inducing ligand (APRIL).⁵
Other Applications Reported In Literature	Immunohistochemistry: Suitable for use at concentration of 5-15 µg/mL. Blocking: In a functional ELISA, 0.075-0.3 µg/mL of this antibody will block 50% of the binding of 50 ng/mL of Recombinant Human BAFF/BLyS/TNFSF13B o immobilized Recombinant Human TACI/TNFRSF13B Fc Chimera coated at 1 µg/mL (100 µL/well). At 10 μg/mL, this antibody will block > 90% of the binding.
PubMed	TACI
Manufacturer - Specificity	Goat Anti-Human Transmembrane Activator & CAML Interactor (TACI) recognizes Human TACI. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831856
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.01EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human TACI (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-T221-25ug-safety-datasheet.pdf