Anti-Human VE-Cadherin - 100 µg

CyTOF®, FC, ICC, WB

VE-Cadherin

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Vascular endothelial-cadherin (VE-Cadherin) also known as cadherin-5 is an endothelial specific, homophilic adhesion molecule located at the lateral cell surface.1 VE-Cadherin is crucial for the proper assembly of vascular structures and the maintenance of vascular integrity.2 It plays a pivotal role in the formation, maturation and remodeling of the vascular wall.3 VE-cadherin is a positive and endothelial cell-specific regulator of transforming growth factor-beta (TGF-beta) signaling. Therefore, the reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signaling is impaired.4

Immunocytochemistry: This antibody has been tested on human endothelial cells (HUVEC) and can be used with the appropriate secondary reagents at the concentration of 5-10 μg/mL. Cells were fixed with 4% paraformaldehyde in PBS at room temperature for 20 minutes, then blocked with 0.1% Triton X-100, 10% normal donkey serum of PBS and 1% BSA at room temperature for 45 minutes.
CyTOF-ready:Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Goat Anti-Human Vascular Endothelial Cadherin (VE-Cadherin) recognizes Human VE-Cadherin. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

NS0-Derived Recombinant Human VE-Cadherin Extracellular Domain

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