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Human IRF5 antibody

Human IRF5 antibody

Item no.	NKM-AIR0611-100ul
Manufacturer	NKMAX
Amount	100 ul
Quantity options	100 ul 50 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, FC, IHC, ICC, ELISA
Clone	10T1
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Conjugate/Tag	Unconjugated
Citations	Mario B., et al, (2007) J. Virology 81(9):4473-4481. Ning S., et al, (2005) J. Virology 79:11671-11676. Barro M, Patton JT. Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7. (J Virol. 2007){https://pubmed.ncbi.nlm.nih.gov/17301153/} Watanabe T, et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. (J Clin Invest. 2008){https://www.ncbi.nlm.nih.gov/pubmed/18188453} Ye L, et al. Methamphetamine enhances Hepatitis C virus replication in human hepatocytes. (J Viral Hepat. 2008){https://pubmed.ncbi.nlm.nih.gov/18307590/} Pandey AK, et al. NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. (PLoS Pathog. 2009){https://www.ncbi.nlm.nih.gov/pubmed/19578435} Polioudakis D, et al. A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes. (Nucleic Acids Res. 2013){https://pubmed.ncbi.nlm.nih.gov/23303785/} Steinhagen F, et al. IRF-5 and NF-κB p50 co-regulate IFN-β and IL-6 expression in TLR9-stimulated human plasmacytoid dendritic cells. (Eur J Immunol. 2013){https://pubmed.ncbi.nlm.nih.gov/23616277/} He H, et al. Immobilized heavy chain-hyaluronic acid polarizes lipopolysaccharide-activated macrophages toward M2 phenotype. (J Biol Chem. 2013){https://pubmed.ncbi.nlm.nih.gov/23878196/} O Carroll C, et al. Identification of a unique hybrid macrophage-polarization state following recovery from lipopolysaccharide tolerance. (J Immunol. 2014){https://pubmed.ncbi.nlm.nih.gov/24337373/} Chionh YT, et al. Protease-activated receptor 1 suppresses Helicobacter pylori gastritis via the inhibition of macrophage cytokine secretion and interferon regulatory factor 5. (Mucosal Immunol. 2015){https://pubmed.ncbi.nlm.nih.gov/24866378/} Steinhagen F, et al. IRF5 and IRF8 modulate the CAL-1 human plasmacytoid dendritic cell line response following TLR9 ligation. (Eur J Immunol. 2016){https://pubmed.ncbi.nlm.nih.gov/26613957/} Li D, et al. Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality. (Sci Rep. 2016){https://pubmed.ncbi.nlm.nih.gov/27481535/} Koelzer VH, et al. Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer. (Oncoimmunology. 2017){https://pubmed.ncbi.nlm.nih.gov/28507795/} Xiao Y, et al. An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway. (Mol Med. 2017){https://pubmed.ncbi.nlm.nih.gov/28620671/} Chen X, et al. MicroRNA-302a suppresses influenza A virus-stimulated interferon regulatory factor-5 expression and cytokine storm induction. (J Biol Chem. 2017){https://pubmed.ncbi.nlm.nih.gov/29046356/}
NCBI	NP_116032.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	interferon regulatory factor 5,irf5
Similar products	IRF5, AIR0611-10ug, AIR0611-20ug, AIR0611-50ug, AIR0611-100ug, AIR0611-250ug, AIR0611-500ug, AIR0611-1mg, AIR0611-10, AIR0611-20, AIR0611-50, AIR0611-100, AIR0611-250, AIR0611-500, AIR0611-1
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	ELISA, WB, ICC/IF, IHC, FACS
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Description	Interferon regulatory factor 5 (IRF-5) is a member of IRF family, which plays a critical role in the regulation of genes induced by viral infection, immunostimulation and cell growth regulation. The expression of IRF-5 is limited to lymphoid organs, dendritic cells, and peripheral blood lymphocytes, but is not expressed in numerous leukemia and lymphoma cell lines. Three IRFs (IRF-3, IRF-5, IRF-7) function as direct transducers of virus-mediated signaling and play a critical role in the expression of type I interferon genes and some chemokines.
Concentration	1mg/ml (determined by BCA assay)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Immunogen	Recombinant human IRF-5 (176-240aa) purified from E. coli
Ab Usage	The antibody has been tested by ELISA, Western blot, ICC/IF, FACS and IHC analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Antigen Species	Human
Clonality	Monoclonal
Ab Purification Comment	By protein-A affinity chromatography
Gene Category	Hormones & Cytokines
Manufacturer - Search Terms	IRF5, AIR0611-10ug, AIR0611-20ug, AIR0611-50ug, AIR0611-100ug, AIR0611-250ug, AIR0611-500ug, AIR0611-1mg, AIR0611-10, AIR0611-20, AIR0611-50, AIR0611-100, AIR0611-250, AIR0611-500, AIR0611-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 9/4/2025

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