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GRK2 Antibody

GRK2 Antibody

Item no.	OACA03053
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Sarcoma Cell Biology Cytoskeleton Immunohistochemistry ELISA Primary Antibodies Immunostaining small GTPases Ras Subfamily
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1] cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.Benovic J.L., Stone W.C., Huebner K., Croce C., Caron M.G., Lefkowitz R.J.FEBS Lett. 283:122-126(1991) [2] High expression of beta-adrenergic receptor kinase in
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ADRBK1;adrenergic beta receptor kinase 1;BARK1;beta-adrenergic receptor kinase 1;beta-ARK-1;BETA-ARK1;G-protein coupled receptor kinase 2.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GRK2
Gene Fullname	G protein-coupled receptor kinase 2
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
Nucleotide accession_num	NM_001619
Protein accession_num	NP_001610
Protein name	Beta-adrenergic receptor kinase 1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Beta-adrenergic receptor kinase 1 protein (2-221AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/25/2025

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