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TACE Antibody

TACE Antibody

Item no.	PRS-1131-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Quantity options	0.02 mg 0.1 mg
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Neural Adhesion Molecules Antibodies Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ICC, ELISA
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Wang et al. Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation. Mol Cell Biol. 2006 ;26(14):5421-35. PMID: 16809777 McGowan et al. ADAM-17 expression in breast cancer correlates with variables of tumor progression. Clin Cancer Res. 2007;13(8):2335-43. PMID: 17438092 Hurtado et al. TACE/ADAM17-TNF-alpha pathway in rat cortical cultures after exposure to oxygen-glucose deprivation or glutamate. J Cereb Blood Flow Meta. 2002 ;22(5):576-85. PMID: 11973430 Pradillo et al. TNFR1 upregulation mediates tolerance after brain ischemic preconditioning. J Cereb Blood Flow Metab. 2005;25(2):193-203.PMID: 15647744 McGowan et al. ADAM-17 predicts adverse outcome in patients with breast cancer. Ann Oncol. 2008;19(6):1075-81. PMID: 18238782 García-Bueno et al. Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats. Biol Psychiatry. 2005;57(8):885-94. PMID: 15820709 Romera et al. In vitro ischemic tolerance involves upregulation of glutamate transport partly mediated by the TACE/ADAM17-tumor necrosis factor-alpha pathway. J Neurosci. 2004;24(6):1350-7. PMID: 14960606 Zimmermann et al. Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines. J Neurochem. 2004;90(6):1489-99PMID: 15341532 Ge et al. Soluble TNF Regulates TACE via AP-2α Transcription Factor in Mouse Dendritic Cells. J Immunol. 2017;198(1):417-427PMID: 27852742 Comabella et al. TNF-alpha converting enzyme (TACE) protein expression in different clinical subtypes of multiple sclerosis. J Neurol. 2006;253(6):701-6PMID: 16511637 García-Bueno et al. The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. Psychopharmacology (Berl). 2005 ;180(3):513-22PMID: 15719215 Gatta et l. Inhibition of heme synthesis alters Amyloid Precursor Protein processing. J Neural Transm (Vienna). 2009;116(1):79-88.PMID: 19002554 Wu et al. ADAM-17 over-expression in gallbladder carcinoma correlates with poor prognosis of patients. Med Oncol. 2011;28(2):475-80PMID: 20300969 Bigdeli et al. Preconditioning with sublethal ischemia or intermittent normobaric hyperoxia up-regulates glutamate transporters and tumor necrosis factor-alpha converting enzyme in the rat brain. J Stroke Cerebrovasc Dis. 2009;18(5):336-42. PMID: 19717015 Black et al. Nature 1997;385:729-733 Moss et al. Nature 1997;385:733-736 Mizui et al. Gene 1999;233:67-74 Peschon et al. Science 1998;282:1281-4
NCBI	ADAM17
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	TACE Antibody: CSVP, TACE, NISBD, ADAM18, CD156B, CSVP, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, ADAM 17
Available
Manufacturer - Applications	WB: 0.25-2 μg/mL; ICC: 10 μg/mL; IF: 10 μg/mL. Antibody validated: Western Blot in human and rat samples; Immunocytochemistry in human samples; and Immunofluorescence in human and rat samples. All other applications and species not yet tested.
Shipping Temperature	blue ice or room temperature
Storage Conditions	TACE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 93kD Observed: 93-125kD (Post-modification: 9 N-linked glycosylation)
Manufacturer - Research Area	Apoptosis
Background	TACE Antibody: Tumor-necrosis factor-alpha is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-α is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-α . TNF-α converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.
Protein Gi #	73747889
Purification	TACE Antibody is affinity chromatography purified via peptide column.
Isoforms	Human TACE has 2 isoforms, including isoform A (824aa, 93kD), isoform B (694aa, 78.5kD). This antibody detects only isoform A. Mouse TACE has 2 isoforms, long isoform (827aa, 93.1kD) and short isoform (655aa, 73.9kD). Rat TACE has only one isoform identified so far (827aa, 93kD).
Positive Control 1	PRS-1201-0.1mg
Positive Control 2	PRS-1205-0.1mg
Positive Control 3	PRS-1207-0.1mg
Positive Control 4	PRS-17-001-1pack
Concentration	1 mg/mL
Buffer	TACE Antibody is supplied in PBS containing 0.02% sodium azide.
Homology	Predicted species reactivity based on immunogen sequence: mouse (94.1%)
Manufacturer - Specificity	80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated TACE.
Immunogen	Anti-TACE antibody (1131) was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TACE. The immunogen is located within the last 50 amino acids of TACE.
Clonality	Polyclonal
NCBI Official Name	ADAM metallopeptidase domain 17
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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