CIDE-A Antibody

Blue Ice

23 kDa

CIDE-A Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase DFF40/CAD, which is chaperoned and inhibited by DFF45/ICAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is expressed in many tissues.

Trial Size

3114595

PRS-1303-0.1mg

1 mg/ml

CIDE-A antibody can be used for detection of CIDE-A by Western blot at 2 μ g/mL. An approximately 23 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

CIDE-A antibody was raised against a 18 amino acid peptide near the carboxy terminus of human CIDE-A.

The immunogen is located within the last 50 amino acids of CIDE-A.

cell death-inducing DFFA-like effector a

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.