Caspase-12 Antibody (Large)

Blue Ice

Predicted: 48 kD

Observed: 46 kD

Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Trial Size, Cell Treatment

2094806

Mouse Caspase-12 has one isoform (419aa, 48kD). Rat Caspase-12 has one isoform (420aa, 48kD) and human Caspase-12 also has two isoforms (39kD and 19kD). 3195 can detect human, mouse and rat.

PRS-1401-0.1mg

PRS-1461-0.1mg

Caspase-12 Antibody is supplied in PBS containing 0.02% sodium azide. (Large)

Caspase-12 (large) antibody is predicted to have no cross reactivity to other members in the caspase family.

Polyclonal

Mus musculus

Optimal dilutions for each application to be determined by the researcher.