TWEAK Antibody

Blue Ice

Predicted: 27 and 36 kD
Observed: 27 and 36 kD

TWEAK Antibody: TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

Trial Size

4507597

Human TWEAK has 2 isoforms, including isoform 1 (249aa, 27kD) and isoform 2 (330aa, 36kD). Mouse TWEAK has one isoform (249aa, 27kD) and Rat TWEAK also has one isoform (249aa, 27kD).

PRS-1303-0.1mg

PRS-10-301-4um

TWEAK Antibody is supplied in PBS containing 0.02% sodium azide.

Anti-TWEAK antibody (3791) was raised against recombinant human TWEAK protein.

tumor necrosis factor (ligand) superfamily, member 12

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.