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CDK5 (phospho Tyr15) Antibody

CDK5 (phospho Tyr15) Antibody

Manufacturer	ProSci
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Neural Signaling Neural Epigenetics Neural Development Antibodies Western Blot Primary Antibodies By Organ Lung Cancer Bladder Cancer Breast Cancer Adhesion Molecule Markers Glial Cell Markers Cytoskeleton Markers Stem Cell Markers Astroglia Markers
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Format	Liquid
Applications	WB
Amount	0.1 mg
Host	Rabbit
Item no.	PRS-79-970-0.1mg
eClass 6.1	32160702
eClass 9.0	32160702
Available
Shipping	blue ice or RT
By Research Area	Phospho-Specific
Immunogen	CDK5 (phospho Tyr15) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine15 (G-T-Y (p)-G-T) derived from Human CDK5.
Applications	Western Blot: 1:500~1:1000
Specificity	The antibody detects endogenous level of CDK5 only when phosphorylated at tyrosine 15.
Predicted Molecular Weight	33 kDa
Purification	Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	1 mg/mL
Storage Conditions	Store antibody at -20˚ C for up to one year.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	Phospho-Specific
Ncbi Official Symbol	CDK5
Accession #	NP_001157882.1
Protein Gi #	4826675
Ncbi Gene Id #	1020
Ncbi Official Symbol	CDK5
Ncbi Official Full Name	cyclin-dependent kinase 5
Ncbi Organism	Homo sapiens
Swissprot #	Q00535
Background	Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM.
Background References 1	Miao Y, et al. (2012)PLoS One 7, e42318. Li P, et al. (2011)Cell 147, 815-26. Nohara A, et al. (2011)J Biol Chem 286, 33457-65.
1st Image Caption	Western blot analysis of extracts from COS7 cells treated with EGF using Phospho-CDK5 (Tyr15) Antibody. The lane on the right is treated with the antigen-specific peptide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 7/4/2024