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PUMA Antibody

PUMA Antibody

Item no.	OAPB01335
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Apoptosis Adenocarcinoma Western Blot ELISA Autophagy Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies Astrocytoma By Organ Colorectal Cancer Breast Cancer Testicular & Prostate Cancer Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ELISA
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Mouse
Conjugate/Tag	Unconjugated
Citations	Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001; 7:683-94.;Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001; 7:673-82.;Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A. 2001; 98:11318-23.;
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	bcl-2-binding component 3;JFY1;JFY-1;p53 up-regulated modulator of apoptosis;p53-upregulated modulator of apoptosis;PUMA.
Similar products	PUMA
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Host	PUMA monoclonal antibody was raised in mouse. Please use anti-mouse secondary antibodies.
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	PUMA antibody can be used for detection of PUMA by Western blot at 2.5 to 5 ug/mL. (Optimal dilution should be determined by user)
Gene symbol	BBC3
Gene Fullname	BCL2 binding component 3
Product format	Liquid. PUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	PUMA monoclonal antibody can be stored at 4C, stable for one year.
Description of target	Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.
Protein name	Bcl-2-binding component 3
Clonality	Monoclonal
Purification	Protein A Purified
Immunogen	Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
Homology	Human; Rat
Concentration	1 mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 12/25/2025

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