PIP5K1A Peptide - middle region (AAP60962)

PIP5K1A

61kDa

8394

PIP5K1A catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2). PtdIns(4, 5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3), another second messenger. The majority of PtdIns(4, 5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation.