PTPN22 Recombinant Protein (OPCD00401)

PTPN22

31 kDa

26191

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules . Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue . Dephosphorylates ZAP70 at its activating 'Tyr-493' residue . Dephosphorylates the immune system activator SKAP2 . Positively regulates toll-like receptor (TLR)-induced type 1 interferon production . Promotes host antiviral responses mediated by type 1 interferon. Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy .

100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.