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EML4-ALK kinase inhibitor 1

EML4-ALK kinase inhibitor 1

Item no.	HY-111752-5mg
Manufacturer	MedChem Express
CASRN	1373409-08-5
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Biochemicals
Specific against	other
Purity	98.02
Citations	[1]Iikubo K, et al. Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1683-1692.
Smiles	CO[C@H]1CC[C@H](NC2=C(CC)N=C(C(N)=O)C(NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=N2)CC1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Anaplastic lymphoma kinase (ALK)
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	580.76
Product Description	EML4-ALK kinase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 110 mg/mL (ultrasonic)
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

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HY-111752-5mg-safety-datasheet.pdf