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Anti-Human CD180 (RP-105) SAFIRE Purified 100ug

Anti-Human CD180 (RP-105) SAFIRE Purified 100ug

Manufacturer	BioGems
Category	Oncology Food Safety Drugs Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	Human
Clone	MHR73-11
Isotype	IgG1 kappa
Format	SAFIRE (Functional)
Applications	FC
Amount	100ug
Host	Mouse
Item no.	12911-25-100
eClass 6.1	32160702
eClass 9.0	32160702
Available
Description	The MHR73-11 monoclonal antibody binds to human CD180, a 105kDA cell surface molecule consisting of extracellular leucine rich repeats (LCC) and a short cytoplasmic tail also known as Bgp-95 and RP105. CD180 is expressed on B cells, dendritic cells, monocytes, and macrophages. It forms a cell surface receptor complex with MD-1 and with TLR4 is involved with the recognition of bacterial lipopolysaccharide (LPS). The MHR73-11 antibody is reported to protect against dexamethasone and irradiation induced apoptosis in B cells
Research Interest	Innate Immunity, Apoptosis
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation	Phosphate-buffered aqueous solution, ph7.2.
References	Miura, Y., Shimazu, R., Miyake, K., Akashi, S., Ogata, H., Yamashita, Y., ... & Kimoto, M. (1998). RP105 is associated with MD-1 and transmits an activation signal in human B cells. Blood, 92(8), 2815-2822. Miguet, L., Lennon, S., Baseggio, L., Traverse-Glehen, A., Berger, F., Perrusson, N., ... & Mauvieux, L. (2013). Cell-surface expression of the TLR homolog CD180 in circulating cells from splenic and nodal marginal zone lymphomas. Leukemia, 27(8), 1748-1750. Koarada, S., Tada, Y., Sohma, Y., Haruta, Y., Suematsu, R., Mitamura, M., ... & Nagasawa, K. (2010). Autoantibody-producing RP105-B cells, from patients with systemic lupus erythematosus, showed more preferential expression of BCMA compared with BAFF-R than normal subjects. Rheumatology, 49(4), 662-670.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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Delivery expected until 5/30/2024