Anti-Autophagy protein 5 ATG5 Antibody

Primary Antibodies

32447 MW

WB: 1:1, 000-1:5, 000
ICC: 1:100-1:500
IHC: 1:50-1:200

Autophagy protein 5

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Involved in autophagic vesicle formation. Conjugation
with ATG12, through a ubiquitin-like conjugating system involving
ATG7 as an E1-like activating enzyme and ATG10 as an E2-like
conjugating enzyme, is essential for its function. The ATG12-ATG5
conjugate acts as an E3-like enzyme which is required for
lipidation of ATG8 family proteins and their association to the
vesicle membranes. Involved in mitochondrial quality control after
oxidative damage, and in subsequent cellular longevity. Plays a
critical role in multiple aspects of lymphocyte development and is
essential for both B and T lymphocyte survival and proliferation.
Required for optimal processing and presentation of antigens for
MHC II. Involved in the maintenance of axon morphology and
membrane structures, as well as in normal adipocyte
differentiation. Promotes primary ciliogenesis through removal of
OFD1 from centriolar satellites and degradation of IFT20 via the
autophagic pathway.

Boster Bio Anti-Autophagy protein 5 ATG5 Antibody catalog # A00240-1. Tested in WB, ICC/IF, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.