Anti-Survivin BIRC5 Antibody

Primary Antibodies

16389 MW

WB: 1:1, 000
ICC: 1:50-1:200
IHC: 1:50-1:200
FC: 1:50-1:100

Baculoviral IAP repeat-containing protein 5

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Multitasking protein that has dual roles in promoting
cell proliferation and preventing apoptosis (PubMed:9859993,
PubMed:21364656, PubMed:20627126). Component of a chromosome
passage protein complex (CPC) which is essential for chromosome
alignment and segregation during mitosis and cytokinesis
(PubMed:16322459). Acts as an important regulator of the
localization of this complex; directs CPC movement to different
locations from the inner centromere during prometaphase to midbody
during cytokinesis and participates in the organization of the
center spindle by associating with polymerized microtubules
(PubMed:20826784). Involved in the recruitment of CPC to
centromeres during early mitosis via association with histone H3
phosphorylated at 'Thr-3' (H3pT3) during mitosis
(PubMed:20929775). The complex with RAN plays a role in mitotic
spindle formation by serving as a physical scaffold to help
deliver the RAN effector molecule TPX2 to microtubules
(PubMed:18591255). May counteract a default induction of apoptosis
in G2/M phase (PubMed:9859993). The acetylated form represses
STAT3 transactivation of target gene promoters (PubMed:20826784).
May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3
and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear
to play vital roles in mitosis (PubMed:12773388, PubMed:16291752).
Isoform 3 shows a marked reduction in its anti-apoptotic effects
when compared with the displayed wild-type isoform
(PubMed:10626797).

Boster Bio Anti-Survivin BIRC5 Antibody catalog # A00379-2. Tested in WB, ICC/IF, IHC, Flow Cytometry applications. This antibody reacts with Human.