Comparison

Anti-MUM1/IRF4 Antibody Picoband® European Partner

Item no. BOS-A00401-2
Manufacturer Boster
Amount 100 ug/vial
Quantity options 100 ug/vial 10 ug 100 ug/vial 100 ug/vial 100 ug/vial 100 ug 100 ug 100 ug 100 ug/vial 100 ug/vial 100 ug/vial 100 ug/vial
Category
Type Antibody Polyclonal
Format Lyophilized
Applications WB, IF, ICC, ELISA
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Citations 1. Shaffer, A. L., Emre, N. C. T., Lamy, L., Ngo, V. N., Wright, G., Xiao, W., Powell, J., Dave, S., Yu, X., Zhao, H., Zeng, Y., Chen, B., Epstein, J., Staudt, L. M. IRF4 addiction in multiple myeloma. Nature 454: 226-231, 2008.
2. Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997). Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25. Genomics 37 (2): 229–33.
3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). Novel MITF targets identified using a two-step DNA microarray strategy. Pigment Cell Melanoma Res. 21 (6): 665–76.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias 70 kDa ribosomal protein S6 kinase 1 antibody,KS6B1_HUMAN antibody,p70 alpha antibody,P70 beta 1 antibody,p70 ribosomal S6 kinase alpha antibody,p70 ribosomal S6 kinase beta 1 antibody,p70 S6 kinase alpha antibody,P70 S6 Kinase antibody,p70 S6 kinase alpha 1 antibody,p70 S6 kinase alpha 2 antibody,p70 S6K antibody,p70 S6K-alpha antibody,p70 S6KA antibody,p70(S6K) alpha antibody,p70(S6K)-alpha antibody,p70-alpha antibody,p70-S6K 1 antibody,p70-S6K antibody,P70S6K antibody,P70S6K1 antibody,p70S6Kb antibody,PS6K antibody,Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody,Ribosomal protein S6 kinase beta 1 antibody,Ribosomal protein S6 kinase beta-1 antibody,Ribosomal protein S6 kinase I antibody,RPS6KB1 antibody,S6K antibody,S6K-beta-1 antibody,S6K1 antibody,Serine/threonine kinase 14 alpha antibody,Serine/threonine-protein kinase 14A antibody,STK14A antibody
Available
Manufacturer - Category
Primary Antibodies
Storage Conditions
At -20°C for one year from date of receipt.
After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.
Avoid repeated freezing and thawing.
Observed Molecular weight
60 kDa
Calculated Molecular weight
52588 MW
Clonality
Polyclonal
Application Details
Western blot, 0.25-0.5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml
Gene Name
IRF4
Gene Full Name
Serine/threonine-protein kinase AtPK1/AtPK6
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.
Immunogen
E.coli-derived human MUM1/IRF4 recombinant protein (Position: A163-Q419). Human IRF4 shares 93.4% amino acid (aa) sequence identity with mouse IRF4.
Contents
Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Purification
Immunogen affinity purified.
Reconstitution
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category
Signal Transduction, Signaling Pathway, Small G Proteins
Protein Name
Serine/threonine-protein kinase AtPK1/AtPK6
Protein Function
Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.
Subcellular Localization
Cytoplasm. Nucleus.
Description
Boster Bio Anti-MUM1/IRF4 Antibody Picoband® catalog # A00401-2. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity
Expressed in all tissues.
Manufacturer - Alias
70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Manufacturer - Cross Reactivity
No cross reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug/vial
Available: In stock
available

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